From Frankfurt or Wiesbaden main station, take the S-Bahn line S1 or S2 to Frankfurt-Höchst station. From here, take the M55 / X53 bus or a taxi.
Alternatively, you can take the S-Bahn line S1 or S2 to Frankfurt Höchst Farbwerke station, and from there take the X53 bus or walk to the venue in about 7 minutes.
Information on disabled access:
The Frankfurt Höchst Farbwerke S-Bahn station is not barrier-free. We therefore recommend getting off at the Höchst Bahnhof S-Bahn station and taking a bus or taxi to the Jahrhunderthalle. The platforms at Höchst station are accessible except for tracks 7 & 8.
For further information, please use the Deutsche Bahn Mobility Service or visit bahnhof.de.